It typically costs $50 to $150 to adopt a domestic shorthair from a shelter or rescue organization. The adoption fee often covers an initial exam, preventatives, microchipping, spay/neuter, and vaccines. There are no pedigree domestic shorthair breeders, but you can certainly find backyard breeders selling litters of domestic shorthairs. We recommend adopting from a rescue organization or shelter to support their life-saving work and to directly rescue a cat in need.